NIH-HL-20-814 NOSI (w links to R01 Clinical Trial and Clinical Trial Not Allowed) The Influence of Host Resilience on Heterogeneity of Acute Respiratory Distress Syndrome/Acute Lung Injury

This NOSI seeks to support investigation into the factors and molecular mechanisms that address the heterogeneity dictated by the host resilience. Research on general host responses to injurious challenges and their effects on lung function as well as mechanisms that impact susceptibility to ARDS is not considered to be responsive to this announcement.

This NOSI encourages, but is not limited to, research applications in the following areas:

Reeve Foundation COVID-19 Grants

The aim of the Reeve Foundation’s new Quality of Life (QOL) grants program is to address social isolation during the COVID-19 pandemic with the goal of enhancing connectedness of people living with paralysis and their caregivers to their communities and preventing adverse health outcomes.

Though we are looking to the field for innovative ways to address the program’s aim and goals, funds may support programs and projects to:

NOT-AI-20-065: Availability of Emergency Awards for Limited Clinical Trials to Evaluate Therapeutic and Vaccine Candidates Against SARS-CoV-2

This Notice of Special Interest encourages cooperative agreement applications for implementation of investigator-initiated high-risk clinical trials, as defined by NIAID in PAR-18-633 and NOT-AI-16-084, that will augment ongoing and planned clinical trials of therapeutic and vaccine candidates directed against SARS-CoV-2 to evaluate:

NOT-MD-20-025: Simulation Modeling and Systems Science to Address Health Disparities

Support investigative and collaborative research focused on developing and evaluating simulation modeling and systems science (SMSS) to understand and address minority health and health disparities. Use SMSS to:
•Foster trans-disciplinary partnerships and collaborations in understanding the etiology and causal pathways of health disparities
•Identify modifiable barriers and cost-effective factors to reduce and eventually eliminate health disparities
•Improve patient safety and reduce medical errors for populations affected by health disparities

Emergency Awards: RADx-RAD Multimodal COVID-19 surveillance methods for high risk clustered populations (R01 Clinical Trial Optional)

NIH is issuing this Funding Opportunity Announcement (FOA) in response to the declared public health emergency issued by the Secretary, HHS, for 2019 Novel Coronavirus (COVID-19). This emergency FOA provides an expedited funding mechanism as part of the Rapid Acceleration of Diagnostics-Radical (RADx-rad) initiative.